While away in UK and France, I didn't check my email once, nor did I have a cell phone (mobile). Occasionally I felt uneasy about this. I guess I experienced technological cold turkey. When I heard a ringtone, I'd reach for my phone and then stop short out of habit. I phoned home a few times, and that was the only time I had contact with NY.
In the long run, the only thing I truly missed was text messaging, but even this I survived.
Now I recommend that everyone try taking a holiday from being totally reachable. It's hard to do in while vacationing somewhere in the US perhaps. Still, try even for one day turning off your cellphone, your pager, your laptop, whatever. Take a long walk or drive away from your hometown and listen to silence for once. Reach out and touch...the off button.